Milk Thistle/SAMe is a popular supplement for pets, offering a combination of milk thistle and SAMe (S-adenosylmethionine). As a nutraceutical, it’s derived from natural substances and can be recommended by veterinarians to support overall health and protect against chronic diseases in pets. This supplement is particularly beneficial for liver health, acting as a protectant and antioxidant for pets suffering from acute liver injury, chronic liver disease, and hepatic lipidosis. It can also be a valuable support for pets on medications that may cause liver irritation or after ingesting certain toxins.
Furthermore, research indicates that the combined use of milk thistle and SAMe may positively impact brain function in older dogs experiencing cognitive decline. However, it is crucial to consult your veterinarian before administering this supplement to your pet.
A well-known over-the-counter option is Denamarin®, which contains silybin, the active compound in milk thistle, along with SAMe. Denamarin® is marketed for both dogs and cats with liver disease, and veterinarians may also prescribe it for horses, birds, ferrets, and rabbits. In some cases, your vet might suggest a compounded formulation of milk thistle/SAMe if commercially available options aren’t suitable for your pet’s specific needs, such as difficulty swallowing pills or unique dosage requirements. Compounded medications are custom-made by a veterinarian or pharmacist and are not FDA-approved.
How Milk Thistle/SAMe Works for Your Pet
The synergistic action of SAMe and milk thistle provides significant benefits for pets. SAMe has demonstrated an ability to protect liver cells from damage and may aid in their repair and regeneration. Milk thistle’s primary active compound, silybin, possesses potent antioxidant and anti-inflammatory properties.
Two main commercially available forms of milk thistle and SAMe exist: Denamarin® and Denamarin® Advanced. The silybin in Denamarin® is known for its superior absorption in dogs compared to other milk thistle extracts. Denamarin® Advanced features a proprietary formula designed for enhanced absorption and efficacy, and it is exclusively available through veterinarians.
It’s important to note that nutraceuticals are not regulated by the FDA. Denamarin® is a patented formulation recognized as a milk thistle/SAMe product. Discussing the suitability of these supplements for your pet with your veterinarian is highly recommended.
Administering Milk Thistle/SAMe
Always adhere to the dosage instructions provided on the product label or by your veterinarian. For optimal absorption, administer the supplement on an empty stomach at least one hour before feeding. If necessary, it can be given with a small treat or a bite of food.
For cats, it’s advisable to follow tablet administration with 3-6 milliliters (mL) of water to ensure the tablet reaches the stomach effectively. Enteric-coated tablets of Denamarin® or milk thistle/SAMe should not be split or crushed.
What to do if a dose is missed:
If you forget to administer a dose, contact your veterinarian for guidance. Typically, you may be advised to give the missed dose when you remember, or if the next dose is approaching, skip the missed one and continue with your regular schedule. Avoid giving double doses.
Potential Side Effects of Milk Thistle/SAMe
Milk Thistle/SAMe is generally well-tolerated by most pets. However, rare side effects may include decreased appetite, vomiting, or diarrhea.
In case of accidental human ingestion:
While milk thistle and SAMe are used in human medicine, dosages and side effects can differ. If a person accidentally ingests pet medication containing these ingredients, contact a physician or the national Poison Control Center hotline immediately at 800-222-1222.
Monitoring while on medication:
Your veterinarian may recommend specific monitoring or routine tests based on your pet’s individual health, other medications they are taking, or the condition for which the supplement was prescribed.
Contact your veterinarian if:
- Severe side effects occur.
- Your pet’s condition deteriorates or fails to improve.
- You suspect an overdose.
- You have further questions or concerns about using Denamarin® or milk thistle/SAMe.
Managing Milk Thistle/SAMe Overdose
Overdoses of Milk Thistle/SAMe are uncommon. Signs of an overdose can include vomiting, diarrhea, or loss of appetite.
If you suspect an overdose, contact your veterinarian, seek emergency veterinary care, or call an animal poison control center immediately. Consultation fees may apply.
Storage Recommendations for Milk Thistle/SAMe
Denamarin® should be stored at controlled room temperatures, not exceeding 86°F (30°C). Keep the container tightly closed to protect it from moisture and light. Always verify storage requirements on the product label.
Compounded medications require storage according to the instructions provided by the compounding pharmacy. Ensure all medications are kept out of reach of children and pets.
Frequently Asked Questions about Milk Thistle/SAMe
Can milk thistle reverse liver damage in dogs?
SAMe, a component of the milk thistle/SAMe combination, has shown promise in protecting liver cells and aiding in their repair. However, its ability to fully reverse liver damage depends on the type and severity of the condition. Milk thistle primarily acts as an antioxidant and anti-inflammatory agent. It’s essential to consult your veterinarian to determine if this supplement is appropriate for your dog’s specific situation, considering their medical history and risk factors.
The content for this article was written and reviewed by veterinary professionals. No compensation has been received from the manufacturer for its creation. Information is sourced from public resources and the manufacturer.
References
- Center SA, Warner KL, McCabe J, Foureman P, Hoffmann WE, Erb HN. Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. American Journal of Veterinary Research. 2005;66(2):330-341.
- Center SA, Randolph JF, Warner KL, et al. The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats [published correction appears in J Vet Intern Med. 2006 Mar-Apr;20(2):465]. Journal of Veterinary Internal Medicine. 2005;19(3):303-314.
- Rème CA, Dramard V, Kern L, Hofmans J, Halsberghe C, Mombiela DV. Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial. Veterinary Therapeutics. 2008;9(2):69-82.
- PetMD. Milk Thistle/SAMe. https://www.petmd.com/dog/general-health/what-veterinary-compounding-pharmacy
- Chewy. Milk Thistle/SAMe Oral. https://www.chewy.com/milk-thistlesame-compounded-oral/dp/543590?utm_source=petmd.com&utm_medium=referral&utm_campaign=pet-medication&utm_term=Milk+Thistle%2FSAMe&utm_content=/pet-medication/milk-thistle-same
- Chewy. Denamarin®. https://www.chewy.com/brands/denamarin-7130?utm_source=petmd.com&utm_medium=referral&utm_campaign=pet-medication&utm_term=Denamarin%C2%AE&utm_content=/pet-medication/milk-thistle-same
- Pet Poison Helpline. https://www.petpoisonhelpline.com/
- ASPCA Animal Poison Control. https://www.aspca.org/pet-care/animal-poison-control
- Vetfolio. https://www.vetfolio.com/learn/article/effect-of-s-adenosylmethionine-tablets-on-the-reduction-of-age-related-mental-decline-in-dogs-a-double-blinded-placebo-controlled-trial
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