Osteoarthritis (OA) is a prevalent and often painful condition affecting millions of dogs. Fortunately, innovative treatments like Galliprant are available to help manage pain and inflammation, allowing canine companions to maintain an active and comfortable life. This article delves into what Galliprant is, how it works, and crucial information for dog owners considering this medication.
What is Galliprant?
Galliprant, containing the active ingredient grapiprant, is a non-steroidal anti-inflammatory drug (NSAID) specifically designed for the control of pain and inflammation associated with osteoarthritis in dogs. It stands out as a new class of anti-inflammatory that targets the root causes of canine OA pain. Galliprant can be safely administered to dogs as young as 9 months of age, provided they weigh at least 8 lbs, and is indicated even for the earliest diagnosed stages of the condition. The pork liver-flavored chewable tablets are scored, making them easy to administer. It’s important to note that Galliprant is a prescription medication and requires a veterinarian’s order.
How Does Galliprant Work?
Galliprant functions as a first-in-class non-COX-inhibiting prostaglandin receptor antagonist. Its mechanism of action centers on specifically blocking the EP4 receptor, which is identified as the primary mediator of pain and inflammation in canine osteoarthritis. Unlike some other NSAIDs, Galliprant’s targeted approach minimizes the impact on gastrointestinal, kidney, and liver functions, preserving their essential homeostatic roles. This targeted action helps dogs with OA remain comfortable and active without compromising vital organ systems.
Benefits of Galliprant
- Targets Osteoarthritis Pain and Inflammation: Galliprant is specifically indicated for the treatment of pain and inflammation associated with canine osteoarthritis.
- Early Intervention: It is safe and effective for young dogs (9+ months, weighing 8+ lbs), allowing for early management of OA.
- Preserves Organ Function: By targeting the EP4 receptor, it reduces the impact on gastrointestinal, kidney, and liver homeostasis.
- Ease of Administration: The pork liver-flavored, scored tablets simplify the process of giving medication to your pet.
- Improved Mobility: Galliprant helps dogs with osteoarthritis maintain an active lifestyle and remain pain-free.
Important Information and Cautions
Galliprant is intended for use in dogs aged 9 months or older, weighing 8 lbs or more. It is not for use in cats or humans. Always keep this medication out of reach of children and pets to prevent accidental ingestion or overdose. Store Galliprant at or below 86°F (30°C) in a secured location.
Safety and Contraindications:
- The safe use of Galliprant has not been evaluated in dogs younger than 9 months, those weighing less than 8 lbs, dogs intended for breeding, or pregnant or lactating dogs.
- Galliprant should not be used in dogs with a known hypersensitivity to grapiprant.
- Long-term use of Galliprant may require appropriate monitoring.
- Concurrent use with other anti-inflammatory drugs, including COX-inhibiting NSAIDs or corticosteroids (like aspirin, carprofen, meloxicam, or prednisone), has not been studied and should be avoided. If additional pain relief is needed, a non-NSAID/non-corticosteroid analgesic may be necessary.
- The effects of Galliprant on dogs with cardiac disease have not been studied.
- It is unknown if dogs with a history of hypersensitivity to sulfonamide drugs will exhibit hypersensitivity to Galliprant, as it is a methylbenzenesulfonamide.
What to Discuss with Your Veterinarian:
Before administering Galliprant, it is crucial to inform your veterinarian about:
- Your dog’s complete medical history, including any history of cardiac disease.
- Whether your dog is used for breeding, or is pregnant or lactating.
- Any other medications your dog is currently taking, especially other anti-inflammatory drugs.
- Any side effects your dog has experienced from previous medications.
- Any digestive issues (bloody or mucoid stool, vomiting, diarrhea, decreased appetite).
- Other medical problems or allergies your dog may have.
Administration and Potential Side Effects
Dosage:
The typical dose of Galliprant is 0.9 mg/lb (2 mg/kg) administered orally once daily. Your veterinarian will determine the lowest effective dose for the shortest duration necessary, based on your dog’s individual response.
Missed Doses:
If you miss a dose of Galliprant, contact your veterinarian for guidance. Do not administer a double dose.
Overdose:
In case of accidental overdose, contact your veterinarian or a veterinary emergency room immediately.
Potential Side Effects:
While generally well-tolerated, potential adverse reactions in dogs receiving Galliprant may include vomiting, diarrhea, decreased appetite, and tiredness.
What to Avoid:
- Do not give other medications to your pet while on Galliprant unless specifically approved by your veterinarian.
- Do not administer to cats or dogs weighing less than 8 lbs.
- Avoid giving Galliprant concurrently with other NSAIDs or corticosteroids.
Galliprant offers a promising option for managing osteoarthritis pain and inflammation in dogs, helping them live fuller, more active lives. Always consult with your veterinarian to determine if Galliprant is the right choice for your canine companion.
